Influence of the glutathione s-transferase gene polymorphisms on the susceptibility to basal cell skin carcinoma.

Investigation of Interleukin-17 Gene Polymorphisms and Serum Levels in Patients with Basal Cell Carcinoma of the Skin

Glutathione S-Transferase, N-Acetyltransferase, Cytochrome P450 Polymorphisms in Patients with Basal Cell Carcinoma

Background: GST, NAT and CYP polymorphisms have been shown to influence the level of oxidative DNA damage. Also, there is a consensus that ROS play part in the epidermal carcinogenesis. Aim: Our purpose was to investigate the GST, NAT and CYP polymorphism in patients with skin cancer. Material and Methods: Ninety seven subjects, 34 women and 63 men, with basal cell carcinoma, and 117 healthy co...

Investigation of the Relationship between Genetic Polymorphisms in GSTM1 and GSTT1 Genes and Susceptibility to Lung Functional Abnormalities in Workers Exposed to Air Pollutants at Isfahan Steel Plant

Introduction: Gaseous air pollutants can cause oxidative stress, which can lead to lung damage by inducing inflammation. Polymorphisms in the glutathione S-transferase (GST) gene are involved in the pathogenesis of many diseases, including lung disease. Two glutathione S-transferase Mu 1 (GSTM1) and glutathione S-transferase theta 1 (GSTT1) genes belong to this family, in which deletions occur ...

Mutations of p53 Gene in Skin Cancers: a Case Control Study

Background: The most frequently mutated tumor suppressor gene found in human cancer is p53. In a normal situation, p53 is activated upon the induction of DNA damage to either arrest the cell cycle or to induce apoptosis. However, when mutated, p53 is no longer able to properly accomplish these functions. The aim of this study was to investigate the expression of p53 gene in cases of skin cancer...

Polymorphisms of glutathione S-transferase in skin cancers in a Japanese population.

Variations in the Glutathione S-transferase (GST) supergene family have been reported to influence cancer susceptibility in Caucasian. However the genetic backgrounds and skin types are quite different between Caucasian and non-Caucasian. We therefore investigated the distribution of GST gene polymorphism in non-Caucasian population to ascertain the role of this polymorphism in skin carcinogene...